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Biochemical and Histological changes associated with Amoxicillin, Paracetamol and Their Mixture on Rabbits
CHAPTER (2) LITERATURE REVIEW4
2.1Rabbits as Experimental Animals...4
2.2Antibiotics4
2.2.1Amoxicillin.5
2.3Analgesic................7
2.3.1Paracetamol....................7
CHAPTER (3) MATERIALS AND METHODS10
3.1Experimental Animals10
3.2Chemicals11
3.3Preparation of Amoxicillin and Paracetamol Solution11
3.4Experimental Design11
3.5Treatments of Animals12
3.6Collection of Blood, Heart , Liver, Brain and Kidney Samples12
3.7Biochemical Analysis13
3.8Determination of Liver Enzymes13
3.8.1Determination of Alanine Aminotransferase13
3.8.2Determination of Aspartate Aminotransferase14
3.8.3Determination of Alkaline Phosphatase15
3.9Non- Protein Nitrogen Constituents16
3.9.1Determination of Urea16
3.9.2Determination of Uric Acid Serum17
3.9.3Determination of Creatinine17
3.10Protein Profile......19
3.10.1Determination of Total Protein19
3.11Histological Work Up19
3.11.1Collection of Samples19
3.11.2Fixation…22
3.11.3Processing22
3.11.4Items of Staining22
3.11.4.1Routine Histological Stain22
3.11.5Examination22
3.12Statistical Analysis22
CHAPTER (4) RESULTS AND DISCUSSION24
4.1Clinical Symptoms and Morphological Notes24
4.2Mortality rate25
4.3Effects on Rabbit's Body Weights..26
4.4Effect on Body Organ28
4.5Hepatosomatic Factors30
4.6Biochemical Effects on Rabbits....31
4.6.1Effects on liver Enzymes31
4.6.2Effects on The Kidney Functions34
4.7Effects on The Blood cell counts36
4.8Histopathology.......40
4.8.1Histopathology of Liver40
4.8.2Histopathology of Kidney44
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